报告题目：Pre-regenerative hydrogel restores complete skin with its appendage

报告人：Dr. Guoming Sun

报告时间：2018年5月29日上午9:00-11:30

报告地点：福州大学旗山校区杨鸿耀楼430

报告摘要：

  Recent progress in skin biology and biomaterial science offers the possibility to make the repair transformed into a regenerative process, which holds great potential and values in clinical wound healing management. Unlike traditional tissue-engineered dermal skin equivalents, we aim to develop instructive hydrogel scaffolds by incorporating functional groups to establish key interactions with endogenous cells in ways that unlock the body’s innate regenerative powers. Based on such philosophy, we designed such novel hydrogel that allows us to create an environment that can trigger, activate different signaling pathways and instruct endogenous cells to proliferate, differentiate, and migrate to self-assemble into complete skin structures. Our in vitro screening study first identified the biodegradable hydrogel that has superior biocompatibility but causes no immune responses. We further tested it for acute cutaneous injuries, including injuries of the pre-existing scars and full-thickness skin injuries. We utilized both murine and porcine models in this study and our results demonstrate that the polysaccharide based hydrogel promoted complete skin regeneration that includes hair follicles, epithelial reticulation, and differentiated dermal, on both pre-existing scarred skin and deep full skin injuries.

报告人简介：

Guoming Sun received his doctoral degree from Cornell University in 2008, followed postdoctoral training at Johns Hopkins University. Subsequently, he joined the Center for Craniofacial Regeneration at Columbia University in the City of New York. His research interests are primarily directed toward developing translational polymeric biomaterials for tissue engineering and regenerative medicine. As the founder of Sunogel Inc., the focus of his entrepreneurial endeavor is to develop pro-regenerative hydrogel scaffolds for scarless wound healing and skin regeneration Dr Sun is an invited peer reviewer for more than 50 journals (e.g., Adavanced materials, ACS Nano etc). He also reviews grants for international organizations (e.g., Netherlands Organisation for Health Research and Development). In addition, he also serves as editorial board members for international journals (e.g., JSM Regenerative Medicine). He received several scholarships, honors and awards. In 2017, Dr. Sun received the Albert Nelson Marquis Lifetime AchievementAward.