2021-05-08 阅读数：
以食品安全与生命健康领域的国家重大需求为导向，聚焦食品安全与生物分析的国际科技前沿，围绕制约我国食品安全与生物分析的关键检测与监测技术开展相关的基础科学研究、共性关键技术与产品研发、产品推广与应用示范。形成4个特色研究方向：（1）复杂样品前处理方法与技术：围绕影响食品安全的环境污染物、农兽药残留、持久性有机污染物、毒素、添加剂等食源性化学危害物开展复杂样品前处理材料、方法、技术的研究与开发；（2）食品安全分析新方法：基于高灵敏光、电、质谱检测技术开展食品中痕量和超痕量有毒有害物质的精准分析新方法研究；（3）食品安全快检技术与仪器：基于新型光电检测技术以及纳米技术开展食品安全在线监测预警溯源、便携式快速检测的关键技术、仪器及配套试剂的研发与成果转化；（4）生物分析与生物成像：围绕与食品污染有关的重大慢性病如肿瘤等相关生物标志物开展体外检测、活细胞成像、活体原位诊断与治疗的新原理和新方法研究。主要研究工作如下：
1. 复杂样品前处理方法与技术
以食品安全与生命健康领域的国家重大需求为导向，聚焦食品安全与生物分析的国际科技前沿，重点围绕影响食品安全的环境污染物、农兽药残留、添加剂以及与生命健康息息相关的多肽/翻译后修饰蛋白质等疾病标志物开展复杂样品前处理新材料、新方法、新技术的研究。
部分代表性研究成果：
1. Ning Zhang, Lishen Su, Suning Man, Xiaoyun Lei, Ting Huang, Chunling Zhu, Lan Zhang, Xiaoping Wu*. Task-specific solid-phase microextraction based on ionic liquid/polyhedral oligomeric silsesquioxane hybrid coating for sensitive analysis of polycyclic aromatic hydrocarbons by gas chromatography-mass spectrometry. Journal of Chromatography A, 2019, 1598, 49-57.
2. Ning Zhang, Xiaoyun Lei, Ting Huang, Lishen Su, Lan Zhang, Zenghong Xie, Xiaoping Wu*. Guanidyl-functionalized polyhedral oligomeric silsesquioxane porous hybrid polymer coating for specific solid phase microextraction of phthalate esters in foodstuff. Chemical Engineering Journal, 2020, 124003.
3.Xiaoyun Lei, Jiaxing Cui, Shuqiang Wang, Ting Huang, Xiaoping Wu*.Preparation of a biomimetic ionic liquids hybrid polyphosphorylcholine monolithic column for the high efficient capillary microextraction of glycopeptide antibiotics. J. Chromatogr. A, 2020, 1623, 461175.
4.Mingyue Zhang, Jing Li, Chao Zhang, Zhifeng Wu, Yixin Yang, Jingguang Li, Fengfu Fu∗, Zian Lin∗. In-situ synthesis of fluorinated magnetic covalent organic frameworks for fluorinated magnetic solid-phase extraction of ultratrace perfluorinated compounds from milk. Journal of Chromatography A, 2020, 1615, 460773.
5. Mingyue Zhang, Xi Yan, Wende Ma, Yu He, Zongwei Cai, Zian Lin*. Facile synthesis of tubular magnetic fluorinated covalent organic frameworks for efficient enrichment of ultratrace polybrominated diphenyl ethers from environmental samples. Talanta, 2021, 221, 121651.
6. Yanxia Li, Hongna Zhang, Yiting Chen, Lu Huang, Zian Lin*, Zongwei Cai*. Core−Shell Structured Magnetic Covalent Organic Framework Nanocomposites for Triclosan and Triclocarban Adsorption. ACS Appl. Mater. Interfaces, 2019, 11, 22492-22500.
7. 白璟,林子俺.共价有机骨架材料在样品前处理中的研究进展.色谱, 2019, 37, 1251-1260.
8. 黄维妮，林子俺. 色谱分析中样品前处理技术的发展动态. 色谱, 2021, 39, 1-3.
9. Wende Ma, Qiong Zheng, Yanting He, Guorong Li, Wenjing Guo, Zian Lin*, Lan Zhang*. Size-controllable synthesis of uniform spherical covalent organic frameworks at room temperature for highly efficient and selective enrichment of hydrophobic peptides. J. Am. Chem. Soc, 2019, 141, 18271-18277.
10. Chaohong Gao, Jing Bai, Yanting He, Qiong Zheng, Wende Ma, Zhixian Lei, Mingyue Zhang, Jie Wu, Fengfu Fu, and Zian Lin*. Postsynthetic functionalization of Zr4+ immobilized core-shell structured magnetic covalent organic frameworks for selective enrichment of phosphopeptides. ACS Appl. Mater. Interfaces, 2019, 11, 13735-13741.
11. Chaohong Gao, Jing Bai, Yanting He, Qiong Zheng, Wende Ma, and Zian Lin*. Post-Synthetic modification of phenylboronic acid-functionalized magnetic covalent organic frameworks for specific enrichment of N‑linked glycopeptides. ACS Sustainable Chem. Eng., 2019, 7, 23, 18926-18934.
2. 食品安全分析新方法
食品中重金属元素的形态分析和生物利用率测定对于客观科学评价食品重金属污染的健康风险和保证食品的安全消费具有重要意义。利用各种ICP-MS联用技术、激光拉曼技术建立了多种适用于各种海产品中各形态砷和汞的分析方法，并利用所建立的分析方法详细研究了海产品中砷形态分布特征，为客观科学评价海产品中砷的健康风险提供技术支撑。构建基于均相免修饰电化学传感方法并，将其应用于畜产品种源成分鉴定；基于暗场成像技术，构建食品安全分析新方法；将热控电极应用于基于功能核酸的ECL传感界面的构建，开发了一系列操作简便、灵敏度高、抗干扰性好的ECL传感器，实现了目标物的原位分析检测。
部分代表性研究成果：
1. Yaohui Lin, Ying Sun, Xusheng Wang, Shilong Chen, Yongning Wu, FengFu Fu*. A universal method for the speciation analysis of arsenic in various seafood based on microwave-assisted extraction and ion chromatography-inductively coupled plasma mass spectrometry, Microchemical Journal, 2020, 159, 105592.
2．KaiTeng Wang, YuanPing Li, YongChen Wu, ZongQing Qiu, ZhenXi Ding, XingJu Wang, Wei Chen, RenJie Wang, FengFu Fu*. Christopher Rensing*, GuiDi Yang*, Improved grain yield and lowered arsenic accumulation in rice plants by inoculation with arsenite-oxidizing Achromobacter xylosoxidans GD03, Ecotoxicology and Environmental Safety, 2020, 206, 111229.
3．Ganga Raj Pokhrel, KaiTeng Wang, HongMao Zhuang, YongChen Wu, Wei Chen, Yan Lan, Xi Zhu, Zhong Li, FengFu Fu*, GuiDi Yang*. Effect of selenium in soil on the toxicity and uptake of arsenic in rice plant, Chemosphere, 2020, 239, 124712.
4．Mingwei Yang, Valery Liamtsau, Changjun Fan, Kelli L. Sylvers, Anthony J. McGoron, Guangliang Liu, FengFu Fu, and Yong Cai*. Arsenic speciation on silver nanofilms by surface-enhanced Raman spectroscopy, Analytical Chemistry, 2019, 91, 8280-8288.
5．Xin Jin, Jianlang Chen, Xiaoxue Zeng, LiangJun Xu, Yongning Wu and FengFu Fu*. A signal-on magnetic electrochemical immunosensor for sensitive detection of saxitoxin using palladium-doped graphitic carbon nitride-based non-competitive strategy, Biosensors and Bioelectronics, 2019, 128, 45-51
6．Xiaobin Huang, Shaohua Wu*, Haocheng Hu, Jianjun Sun. AuNanostar @4-MBA @Au Core-Shell Nanostructure Coupled with Exonuclease III-Assisted Cycling Amplification for Ultrasensitive SERS Detection of Ochratoxin A. ACS Sensors, 2020, 5 (8), 2636-2643.
7．Shaohua Xu, Longhua Guo*, Lifen Chen*, Fang Luo, Bin Qiu*, Zhenyu Lin. Dark field microscope-based single nanoparticle identification coupled with statistical analysis for ultrasensitive biotoxin detection in complex sample matrix. Microchimica Acta, 2020, 187, 413.
8. Yuanjin Zhan, Yanbo Zeng, Lei Li*, Fang Luo, Bin Qiu, Zhenyu Lin, and Longhua Guo*. Ratiometric fluorescent hydrogel test kit for on-spot visual detection of nitrite. ACS Sensors, 2019, 4, 5, 1252-1260.
9. Huifang Zhang, Fang Luo, Peilong Wang⁎, Longhua Guo, Bin Qiu, Zhenyu Lin*. Signal-on electrochemiluminescence aptasensor for bisphenol A based on hybridization chain reaction and electrically heated electrode; Biosensors and Bioelectronics, 2019, 129, 36-41.
3. 食品安全快检技术与仪器
目前针对食品安全的快检技术大多只能进行定性分析，无法进行定量分析，若要进行定量分析，需要配合使用相对大型的仪器设备，不利于家庭和资源匮乏地区的使用，需要开发一些基于便携式设备为读出装置的快速分析技术；对于食品掺假、农残等的检测手段大多是经过样品前处理后采用LC-MS/GC-MS等手段，这些方法大多需要在条件良好的实验室里面进行，目前这方面的研究大多集中在样品前处理以及富集技术上，步骤相对复杂，分析耗时长，成本高。有必要开发无需进行样品前处理的检测技术、以提高检测通量，降低检测成本。同时对于成分极其相近的物质，或者对于其标志物还不明确的物质，采用上述方法无法进行很好的分辨，需要结合化学计量学等手段开发新的方法进行分析检测。
部分代表性研究成果：
1. Huiping Fu, Jiaming Chen, Lijuan Chen, Xi Zhu, Zhuling Chen*, Bin Qiu, Zhenyu Lin, Longhua Guo*, Guonan Chen. A calcium alginate sponge with embedded gold nanoparticles as a flexible SERS substrate for direct analysis of pollutant dyes. Microchimica Acta, 2019, 186(2): 64.
2. Bingyong Lin, Jiaming Chen, Palanisamy Kannan*, Yanbo Zeng, Bin Qiu, Longhua Guo*, Zhenyu Lin. Rapid synthesis of a highly active and uniform 3-dimensional SERS substrate for on-spot sensing of dopamine. Microchimica Acta, 2019, 186(4): 260.
3. Dandan Huang, Jiaming Chen, Li Ding, Longhua Guo*, Palanisamy Kannan*, Fang Luo, Bin Qiu, Zhenyu Lin*. Core-satellite assemblies and exonuclease assisted double amplification strategy for ultrasensitive SERS detection of biotoxin. Analytica chimica acta, 2020, 1110:56-63.
4. Bingyong Lin, Palanisamy Kannan*, Bin Qiu, Zhenyu Lin, Longhua Guo*. On-spot surface enhanced Raman scattering detection of Aflatoxin B1 in peanut extracts using gold nanobipyramids evenly trapped into the AAO nanoholes. Food chemistry, 2020, 307: 125528
5. Bingyong Lin, Jiaming Chen, Yanbo Zeng, Lei Li*, Bin Qiu, Zhenyu Lin, and Longhua Guo*. A facile approach for on-site evaluation of nicotine in tobacco and environmental tobacco smoke. ACS sensors, 2019, 4(7): 1844-1850.
6. Jiaming Chen, Longhua Guo*, Lifen Chen, Bin Qiu, Guolin Hong*, and Zhenyu Lin*. Sensing of hydrogen sulfide gas in the raman-silent region based on gold nano-bipyramids (AuNBPs) encapsulated by zeolitic imidazolate framework‑8. ACS sensors, 2020. (DOI: 10.1021/acssensors.0c01659)
7. Wang Q, Chen M, Zhang J, Dong Y*. Carbon based dots capped tin oxide nanosheets hybridizing with silver nanoparticles for ultra-sensitive surface enhanced raman scattering substrate. Carbon, 2020, 170, 270-276.
8. Huang Yaying, Lin Cuiying*, Luo Fang*, Luo, Fang, Qiu Bin, Guo Longhua, Lin Zhenyu*, Chen, Guonan. Ultrasensitive and Portable Assay for Lead (II) Ions by Electronic Balance as a Readout. ACS Sensors. 2019, 4(9): 2465-2470.
9. Tang Linyue, Huang Yaying, Lin Cuiying*, Qiu Bin, Guo Longhua, Luo Fang, Lin, Zhenyu*. Highly sensitive and selective aflatoxin B1 biosensor based on Exonuclease I-catalyzed target recycling amplification and targeted response aptamer-crosslinked hydrogel using electronic balances as a readout. Talanta, 2020, 214: 120862.
10. Zhixin Li, Caixi Tang, Da Huang, Wenjuan Qin*, Fang Luo, Jian Wang, Longhua Guo, Bin Qiu, Zhenyu Lin*. Sensitive Hyaluronidase Biosensor based on Target-Responsive Hydrogel Using Electronic Balance as Readout. Analytical Chemistry, 2019,91(18):11821-11826.
11. Suyan Qiu, Lijuan Yuan, Yihua Wei, Dawen Zhang, Qinglong Chen, Zhenyu Lin*, Linguang Luo*. DNA template-mediated click chemistry-based portable signal-on sensor for ochratoxin A detection. Food Chemistry, 2019,297,124929.
12. Ma, Xiaoming; Wang, Zhen; He, Shan; Chen, Chaoqun; Luo, Fang; Guo, Longhua; Qiu, Bin; Lin, Zhenyu*; Chen, Guonan; Hong, Guolin*. Development of an immunosensor based on the exothermic reaction between H2O and CaO using a common thermometer as readout. ACS Sensors, 2019, 4(9), 2375-2380.
13. Yanling Huang, Yue Lin, Fang Luo, Peilong Wang*, Jian Wang, Bin Qiu, Longhua Guo, Zhenyu Lin*. Rapid detection of dibutyl phthalate in liquor by a semi-quantitative multicolor immunosensor with naked eyes as readout.Analytical Method, 2019, 11, 524-529.
14.Wei Pan, Mei Wu, Zhenzhu Zheng, Longhua Guo, Zhenyu Lin, Bin Qiu*. Rapid authentication of Pseudostellaria heterophylla (Taizishen) from different regions by near‐infrared spectroscopy combined with chemometric methods. Journal of Food Science, 2020,85(7),2004-2009.
15. 2019年度福建省科技进步一等奖，基于纳米材料形貌变化的可视化传感技术研究及应用，林振宇、郭隆华、陈劲星、邱彬、翁齐彪、苏建峰、许梢华、陈国南
4. 生物分析与生物成像
生物分析和生物成像是一个非常活跃的研究和工程技术领域，它与生物信息学、生物芯片、生物控制论、仿生学、生物计算机等学科一起，处在生命科学和信息科学的交叉区域。它们的共同特征是:探索和揭示出生命系统中信息的产生、存储、传输、加工、转换和控制等基本规律，探讨应用于人类经济活动的基本方法。生命活动的发生和调节是细胞通过生物大分子间(蛋白质-蛋白质、蛋白质-核酸等)相互作用来实现的，因此获取这些信息对与研究基因的表达和蛋白质-蛋白质的相互作用至关重要，而光学成像技术则为解决这些科学研究提供了现实与可能。
我们研究人员一直专注利用各种光学技术对生命科学和生物医疗的各个领域进行探索。近年来，科学家们利用光学技术结合分子生物学方法，不断尝试开发出更为先进的成像工具，以期对体外快速检测、生命活动能有可视化的直观了解，从而进行更为深入和细致的研究。
部分代表性研究成果：
1. Ruijin Zeng, Weijun Wang, Guoneng Cai, Zhenliang Huang, Jiangming Tao, Dianping Tang*, Chengzhou Zhu. Single-atom platinum nanocatalyst-improved catalytic efficiency with enzyme-DNA supermolecular architectures. Nano Energy ,2020, 104931.
2. Guoneng Cai, Zhenzhong Yu, Ping Tong, Dianping Tang*. Ti3C2 MXene quantum dots-encapsulated liposome for photothermal immunoassay using a portable near-infrared imaging camera on smartphone. Nanoscale, 2019, 11, 15659-15667.
3. Lingting Huang, Jialun Chen, Zhonghua Yu,Dianping Tang*. Self-Powered Temperature Sensor with Seebeck Effect Transduction for Photothermal–Thermoelectric Coupled Immunoassay. Analytical Chemistry, 2020, 92, 3, 2809-2814.
4. Zhenzhong Yu, Yun Tang, Guoneng Cai, Rongrong Ren, Dianping Tang*. Paper electrode-based flexible pressure sensor for point-of-care immunoassay with digital multimeter. Analytical Chemistry, 2019, 91, 2, 1222-1226.
5. Zhenzhong Yu, Guoneng Cai, Ping Tong, Dianping Tang*. Saw-toothed microstructure-based flexible pressure sensor as the signal readout for point-of-care immunoassay. ACS Sensors, 2019, 4, 9, 2272-2276.
6. Zhenzhong Yu, Guoneng Cai, Xiaolong Liu, Dianping Tang*. Platinum nanozyme-triggered pressure-based immunoassay using a three-dimensional polypyrrole foam-based flexible pressure sensor. ACS Applied Materials & Interfaces, 2020, 12, 36, 40133-40140.
7. Shuzhen Lv, Kangyao Zhang, Ling Zhu, andDianping Tang*. ZIF-8-assisted NaYF4:Yb,Tm@ZnO converter with exonuclease III-powered DNA walker for near-infrared light responsive biosensor. Analytical Chemistry, 2020, 92, 1470-1476.
8. Shuzhen Lv, Kangyao Zhang, Ling Zhu, Dianping Tang*, Reinhard Niessner, and Dietmar Knopp*. H2‑Based electrochemical biosensor with Pd nanowires@ZIF-67 molecular sieve bilayered sensing interface for immunoassay. Analytical Chemistry, 2019, 91, 12055-12062.
9. Rongjing, H.; Juanxia, S.; Qian, W.; Mingming, C.; Yajie, J.; Lichan, C.; Binhua, D.; Fengfu, F.; Yongqiang, D., Carbon-based dot nanoclusters with enhanced roles of defect states in the fluorescence and singlet oxygen generation. New Journal of Chemistry, 2020,44.16461-16467
10. Li-Jing Han, Xiu-Xin Wu, Zheng-Gen Ma, Yi Li*, Qiao-Hua Wei*. Novel luminescent homo/heterometallic platinum( II ) alkynyl complexes based on Y-shaped pyridyl diphosphines. Dalton Trans., 2020, 49, 8347-8353.
11. Lijing Han, Jing Tang, Qiaohua Wei*, Congrong Chen, Mingdeng Wei*. A hierarchical composite of GeO 2 nanotubes/N-doped carbon microspheres with high-rate and super-durable performance for lithium-ion batteries. Chem. Commun., 2019, 55, 14319-14322.
12. Xueting Liu, Huijun Zhang, Zhiping Song, Liangqia Guo*, Fengfu Fu.Yongning Wu; A ratiometric nanoprobe for biosensing based on green fluorescent graphitic carbon nitride nanosheets as an internal reference and quenching platform; Biosensors and Bioelectronics 2019, 129, 118-123
13. Dongsheng Zhou, Xueting Liu, Xiaotao Liu, Yuanteng Xu*, Ruiqing Chen, Chang Lin, Liangqia Guo*, Fengfu Fu. Ratiometric fluorescent biosensor for microRNAs imaging in living cells; Sensors and Actuators: B. Chemical, 2020, 322, 128632
14. Zhuang Cai, Xiaotao Liu, Xingyu Wang, Zhifeng Chen, Zhiping Song, Yuanteng Xu*, Huilin Tao, Yi Li*, Ruiqing Chen, Liangqia Guo*, Fengfu Fu. Fluorescence imaging of Cys in keratinocytes upon UVB exposure using phenyl doped graphitic carbon nitride Nanosheets-Au nanoparticles nanocomposite; Analytica Chimica Acta, 2019, 1091, 127-134
15. Yanhao Zhang, Yuanyuan Song, Jie Wu, Ruijin Li, Di Hu, Zian Lin* and Zongwei Cai*. Magnetic covalent organic framework as adsorbent and new matrix for enrichment and rapid determination of PAHs and their derivatives in PM2.5 by surface-assisted laser desorption/ionization-time of flight-mass spectrometry.Chem. Commun., 2019, 55, 3745-3748.
16. Qianqian Sun, Chaohong Gao, Wende Ma, Yanting He, Jie Wu, Kailong Luo, Dan Ouyang, Zian Lin*, Zongwei Cai*. High-throughput screening of bisphenols using magnetic covalent organic frameworks as a SELDI-TOF-MS probe. Microchimica Acta, 2020, 187, 370-380.
17. Kailong Luo, Baichuan Yang, Wenjing Guo, Qianqian Sun, Ouyang Dan, Zian Lin* and Zongwei Cai*. Surface-Enhanced Laser Desorption/Ionization Mass Spectrometry for Rapid Analysis of Organic Environmental Pollutants by Using Polydopamine Nanospheres as Substrate. Analyst, 2020,145, 5664-5669.
18. Jie Wu, Dan Ouyang, Yanting He, Hang Su, Baichuan Yang, Jing Li, Qianqian Sun, Zian Lin,* and Zongwei Cai*. Synergistic Effect of Metal-Organic Framework/Gallic Acid in Enhanced Laser Desorption/Ionization Mass Spectrometry. ACS Appl. Mater. Interfaces, 2019, 11, 38255-38264.
19. Dan Ouyang, Kailong Luo, Wende Ma, Jie Wu, Jing Li, Yanting He, Zongwei Cai and Zian Lin*. A spherical covalent-organic framework for enhancing laser desorption/ionization mass spectrometry for small molecule detection. Analyst, 2020, 145, 3125-3130.
20. Zhi Li, Qinrui Fu, Jiamin Ye, Xiaoguang Ge, Jie Wang, Jibin Song* and Huanghao Yang*. Ag+-Coupled Black Phosphorus Vesicles with Emerging NIR-II Photoacoustic Imaging Performance for Cancer Immune-Dynamic Therapy and Fast Wound Healing, Angewandte Chemie International Edition, 2020, 59, 22202-22209.
21. Xiaorong Song, Wei Zhu, Xiaoguang Ge, Renfu Li, Shihua Li, Xian Chen, Jibin Song, Jianping Xie*, Xueyuan Chen* and Huanghao Yang*. A New Class of NIR‐II Gold Nanoclusters Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging, Angewandte Chemie International Edition, 2020, 10.1002/anie.202010870.
22. Shan Chen, Zhifei Xu, Wen Yang, Xiahui Lin, Jingying Li, Juan Li,* and Huanghao Yang. Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction, Angew. Chem. Int. Ed., 2019, 58, 18186-18190.
23. Da Zhang, Youshi Zheng, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang* and Weihong Tan. Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors, Angew. Chem. Int. Ed., Doi: 10.1002/anie.202002145
24. Yifan Jiang, Xin Xu, Xiao Fang, Shuxian Cai, Min Wang, Chao Xing, Chunhua Lu* and Huang-Hao Yang*. A Self-Assembled mRNA-Responsive DNA Nanosphere for Bioimaging and Cancer Therapy in Drug-Resistant Cells, Analytical Chemistry, 2020, 92, 11779-11785.
25. Xiahui Lin, Shuya Liu, Xuan Zhang, Rong Zhu, Shan Chen, Xiaoyuan Chen, Jibin Song* and Huanghao Yang*. An Ultrasound Activated Vesicle of Janus Au‐MnO Nanoparticles for Promoted Tumor Penetration and Sono‐Chemodynamic Therapy of Orthotopic Liver Cancer, Angewandte Chemie International Edition, 2020, 59, 1682-1688.
26. Hongxin Lin, Lijiao Yang, Xuan Zhang, Guoming Liu, Shuangmu Zhuo, Jianxin Chen, Jibin Song*. Emerging Low‐Dimensional Nanoagents for Bio‐Microimaging. Advanced Functional Materials, 2020, 30, 2003147.
27. Jiamin Ye, Zhi Li, Qinrui Fu, Qingqing Li, Xuan Zhang, Lichao Su, Huanghao Yang, Jibin Song*. Quantitative Photoacoustic Diagnosis and Precise Treatment of Inflammation In Vivo Using Activatable Theranostic Nanoprobe. Advanced Functional Materials, 2020, 30 (38), 2001771.
28. Qingqing Li, Xiaoguang Ge, Jiamin Ye, Zhi Li, Lichao Su, Ying Wu, Huanghao Yang, and Jibin Song*. Dual Ratiometric SERS and Photoacoustic Core-Satellite Nanoprobe for Quantitatively Visualizing Hydrogen Peroxide in Inflammation and Cancer, Angew. Chem. Int. Ed., 2020, 10.1002/anie.202015451.