2021-05-08 阅读数：
以食品安全、环境卫生以及生命健康领域的重大需求为导向，聚焦食品、环境、生物分析多领域的科技前沿，围绕制约我国食品安全、环境卫生及生物分析的关键检测与监测技术开展相关的基础科学研究、共性关键技术与产品研发、产品推广与应用示范。形成4个特色研究方向：（1）复杂样品前处理方法与技术；（2）食品安全分析新方法；（3）食品安全快检技术与仪器；（4）生物分析与生物成像。主要研究工作如下：
1.复杂样品前处理方法与技术
围绕影响食品安全和环境卫生的环境污染物、农兽药残留、添加剂等化学危害物以及与生命健康相关的常见临床药物、疾病标志物开展复杂样品前处理材料、方法、技术的研究与开发。
部分代表性研究成果：
1. Jinni Zhang, Jingjing Yan, Canrong Chen, Xiaojing Li, Wen Xie, Yanhui Zhong, Zian Lin* and Zongwei Cai*. Determination of Perfluoroalkyl Carboxylic Acids in Mice Serum and Tissues by Dispersive Solid-Phase Extraction Based on Fluorine-Functionalized Covalent Organic Frameworks Coupled with UPLC-MS/MS. J. Chromatogr. A, 2025,1747,465820.
2. Ziyi Yang, Qing Yu, Yijing Wu, Ying Sun, Jing Tang, Na Lin, Yu He, Zian Lin*. Facile synthesis of hierarchically flower-like hollow covalent organic frameworks for enrichment and metabolic analysis of benzophenone derivatives in mouse serum. J. Chromatogr. A, 2025, 1743, 465718.
3. Xinye Shi, Hang Su, Yuxin Tu, Canrong Chen, Yajing Zhang, Zian Lin* and Zongwei Cai*. Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice. Talanta, 2025, 285, 127398.
4. Fan Wu, Jin Liu, Qiuting Zhang, Yuandi Xue, Jingjing Yan, Kaixing Luo, Yanhui Zhong and Zian Lin*. Capsule-type single-crystal covalent organic frameworks as an advanced chromatographic stationary phase for efficient separation of isomers. Anal Chem., 2025, 97(22), 11815-11823.
5. Wenmin Zhang, Zhiyong Wang, Lan Zhang*. Interface-assisted synthesized covalent organic framework film for efficient extraction of microcystins in aquatic organisms. Talanta, 2025, 282, 127051.
6. Jinhua Xu, Minghui Tang, Jinyu Zhang, Wenmin Zhang, Shiye Xie, Lan Zhang*. Green and controlled synthesis of copper-based tryptophan flower-like chiral metal-organic framework for enantioselective recognition and volatile organic compound separation. J. Chromatogr. A, 2025, 1753, 466020.
7. Jinhua Xu, Minghui Tang, Wenmin Zhang, Shiye Xie, Qianqian Gu, Lan Zhang*. Controlled synthesis of superhydrophilic flower-like hierarchical porous diboronate affinity materials for capturing biomarkers. Anal. Chim. Acta, 2025, 1357, 344053.
8. Zhiyong Wang, Shiye Xie, Wenmin Zhang, Hui Chen, Qingqing Ding, Jinhua Xu, Qidong Yu, Lan Zhang*. Mechanochemical synthesis ionic covalent organic frameworks/cotton composites for pipette tip solid-phase extraction of domoic acid in seafood. Talanta, 2024, 269, 125485.
9. Jinhua Xu, Zhenli Yu, Wenmin Zhang, Shiye Xie, Baodi Liao, Lan Zhang*. Zwitterionic covalent organic nanosheets for selective analysis of domoic acid in marine environment. Anal. Chim. Acta, 2024, 1331, 343343.
10. Wenmin Zhang, Baodi Liao, Shiye Xie, Lan Zhang*. Hollow microporous organic network fiber membrane for efficient extraction of okadaic acid from marine organism. J. Chromatogr. A, 2024, 1736, 465392.
11. Shiye Xie, Baodi Liao, Jing Yu, Wenmin Zhang, Hui Chen, Jinhua Xu, Lan Zhang*. Self-assembled flower-like carbon nanosheets for magnetic solid-phase extraction of microcystins from aquatic organism. J. Chromatogr. A, 2024, 1730, 465139.
12. Jingyi Wang, Wenmin Zhang, Qingqing Ding, Jinhua Xu, Qidong Yu, Lan Zhang*. Flexible filament winding strategy to prepare COF@polyionic liquid-coated fibers for non-selective exclusion of macromolecules in electro-enhanced solid-phase microextraction. Anal. Chim. Acta, 2024, 1306, 342609.
13. Qidong Yu, Wenmin Zhang, Jingyi Wang, Shiye Xie, Baodi Liao, Hui Chen, Qingqing Ding, Lan Zhang*. Thiocarbamide conversion-based nitrogen-rich covalent organic framework coatings for electro-enhanced solid-phase microextraction of bisphenols. J. Chromatogr. A, 2024, 1727, 465000.
14. Hui Chen, Wenmin Zhang, Guancheng Liu, Qingqing Ding, Jinhua Xu, Min Fang, Lan Zhang*. Highly sensitive detection of okadaic acid in seawater by magnetic solid-phase extraction based on low-cost metal/nitrogen-doped carbon nanotubes. J. Chromatogr. A, 2023, 1689, 463772.
15. Qingqing Ding, Wenmin Zhang, Yuheng Guo, Juan Wang, Hui Chen, Lan Zhang*. β-Lactamase Sensitive Probe for Rapid Detection of Antibiotic-Resistant Bacteria with Gas Chromatography-Tandem Mass Spectrometry. Anal Chem., 2023, 95, 6098-6106.
16. Lishen Su, Xuan Zheng, Jingpu Tang, Qingxiang Wang, Lan Zhang, Xiaoping Wu*. Poly(ionic liquid)s threaded into covalent organic framework for synergistic capture of polybrominated diphenyl ethers. J. Hazard. Mater., 2024, 461, 132657.
17. Ting Huang, Xiaoyun Lei, Shuqiang Wang, Chenchen Lin, Xiaoping Wu*. Ionic liquid assisted in situ growth of nano-confined ionic liquids/metal-organic frameworks nanocomposites for monolithic capillary microextraction of microcystins in environmental waters. J. Chromatogr. A, 2023, 1692, 463849.
18. Ting Huang, Ling Yang, Shuqiang Wang, Chenchen Lin, Xiaoping Wu*. Enhanced performance of ZIF-8 nanocrystals hybrid monolithic composites via an in-situ growth strategy for efficient capillary microextraction of perfluoroalkyl phosphonic acids. Talanta, 2023, 259, 124452.
19. Ling Yang, Ting Huang, Shuqiang Wang, Jingpu Tang, Chenchen Lin, Xiaoping Wu*, Development of biomimetic hexapeptide functionalized monolithic material for capillary microextraction of microcystins in environmental waters. Microchem J, 2023, 192, 108942.
20. Shuqiang Wang, Wenning Liu, Xiaoyun Lei, Ting Huang, Guobin Huang, Chenchen Lin, Xiaoping Wu*. Surface amphiphilic hybrid porous polymers based on cage-like organosiloxanes for pipette tip solid-phase extraction of microcystins in water. J. Chromatogr. A, 2024, 1736, 4653904.
21. Shuqiang Wang, Jiansong Huang, Ting Huang, Guobin Huang, Chenchen Lin, Xiaoping Wu*. Gold nanoparticles supported onto zwitterionic polymer capillary monoliths meant for efffcient enrichment of microcystins in water. Talanta, 2025, 286, 127508.
2. 食品安全分析新方法
基于高灵敏光、电、质谱检测技术开展食品和环境中痕量和超痕量有毒有害物质的精准分析新方法研究。
部分代表性研究成果：
1. Weijuan Yang, Dongdong Luo, Siyu Zheng, Yiru Zhang, Zongwen Wang, FengFu Fu*. Screening of cross-reactive aptamers for the detection of 24 quinolones by using a Liebig’s law-guided parallel-series strategy. Anal. Chem., 2024, 96, 8576−8585.
2. Lin Zhang, Siqi Wu, Junfeng Liu, Meiling Ping*, Weijuan Yang*, FengFu Fu*. Isolation of aptamers with excellent cross-reactivity and specificity to sulfonamides towards a ratiometric fluorescent aptasensor for the detection of nine sulfonamides in seafood. Talanta, 2024, 277, 126380.
3. Weibin Chen, Meiling Qiu, Rui Tu, Xiangjun Mu, Fengfu Fu, Mei-Jin Li *. Aggregation-induced near-infrared emission and electrochemiluminescence of an iridium(III) complex for ampicillin sodium sensing. Inorg. Chem., 2023, 62, 11708−11717.
4. Zhoubing Zhang, Xiaorun Jia, Xueqin Xu*. An electrochemical aptasensor for detection of streptomycin based on signal amplification assisted by functionalized gold nanoparticles and hybridization chain reaction. Microchim. Acta, 2023, 190, 152.
5. Yongcong Zhou, Jingwen Zhang, Xiaojing Lai, Yiquan Chen*, Fengfu Fu, Zhenyu Lin, Yongqiang Dong*. Aggregated gold nanoparticles rich in electromagnetic field “hotspots” for surface enhanced Raman scattering. Talanta, 2025, 282, 126948.
6. Wei Lin, Zesong Liu, Jingwen Zhang, Jinhua Xu, Fengfu Fu, Zhenyu Lin, Yiquan Chen*, Yongqiang Dong*. Paper-based SERS chips for the rapid detection of thiram. Spectrochim. Acta A, 2025, 332, 125812.
7. Rongjing Hu, Chenyi Zeng, Jingwen Zhang, Jinhua Xu, Cheng Pan, Zhenyu Lin, Fengfu Fu*, Yongqiang Dong*. Stable aggregated silver nanoparticle in water with strong and wavelength-tunable localized surface plasmon resonance for liquid-state SERS substrates. J. Mol. Liq., 2025, 424, 127113.
8. Xiaolong Fu, Huiying Wu, Zhihong Liu, Pengzhao Wang*, Jiefeng Rong, Fengfu Fu, Zhenyu Lin, Yongqiang Dong*. MoS2 Nanosheets as Substrates for SERS-Based Sensing. ACS Appl. Nano Mater., 2024, 7, 3988-3996.
9. Mingming Chen, Bihang Su, Huiying Wu, Yawen Dai, Tianwen Chen*, Fengfu Fu*, Zhenyu Lin, Yongqiang Dong*. Hydrogel SERS chip with strong localized surface plasmon resonance for sensitive and rapid detection of T-2 toxin. Talanta, 2024, 268, 125329.
10. Mingming Chen, Xiaojing Lai, Bihang Su, Xiancai Jiang, Jinhua Xu, Fengfu Fu*, Zhenyu Lin, Yongqiang Dong*. Rapid detection of tebuconazole based on hydrogel SERS chips. Talanta, 2024, 277, 126309.
11. Chaochen Sun, Miaomiao Yin, Ying Peng, Chen Lin, Yongning Wu, FengFu Fu*, Yue Lin*. The characteristic and bio-accessibility evaluation of mercury species in various kinds of seafood collected from Fujian of China for mercury risk assessment. J. Hazard. Mater., 2025, 482, 136549.
12. Yue Lin, Junfeng Liu, Ying Sun, Shilong Chen, Jianlang Chen, FengFu Fu*. Bio-accessibility and bio-availability evaluation of each arsenic species existing in various edible seaweeds in vitro and in vivo for arsenic risk assessment. Sci. Total Environ., 2024, 946, 174247.
13. Haochen Xu, Yiwei Zhu, Ying Peng, Chaochen Sun, FengFu Fu*, Yue Lin*. A cost-effective method applicable to the speciation analysis of lead in various types of seafood based on short-column ion chromatography-inductively coupled plasma mass spectrometry. J. Anal. At. Spectrom., 2025, 40, 1364.
14. Suning Man, Lei Huang, Yi Zhang, Xiaoping Wu*. Selective sensing of hexavalent chromium in food grains using an electrodeposited bimetallic Au-Pd nanoparticles modified electrode. Electroanal., 2024, 36, e202400028.
15. Yongzhen Qiu, Yexin Zu, Yating Zhang, Yue Lin, Fang Luo*, Zuquan Weng, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin*. One-pot synthesis of highly stable CsPbBr₃@C6H7NO3S composite and its application in nitrite fluorescent sensing. Food Chem., 487 (2025) 144823
16. 黄少坤，谢秀琳，蔡华宾，黄艳玲，林悦*，林振宇*. 以鲁米诺/H2O2作为报告体系的微通道电化学发光传感器用于四环素的检测。分析化学, 2025, 53(3), 356-363。
17. Yanling Huang, Huabin Cai, Fang Luo, Lifen Chen*, Cuiying Lin*, Jian Wang, Longhua Guo, Bin Qiu, Zhenyu Lin*. Protein denaturation inspired microchannel- based electrochemiluminescence sensor for formaldehyde detection. Biosens. Bioelectron., 2025, 267, 116778.
18. Wenmin Zhang, Zhiyong Wang, Lan Zhang*. Interface-assisted synthesized covalent organic framework film for efficient extraction of microcystins in aquatic organisms. Talanta, 2025, 282, 127051.
19. Zhiyong Wang, Shiye Xie, Wenmin Zhang, Hui Chen, Qingqing Ding, Jinhua Xu, Qidong Yu, Lan Zhang*. Mechanochemical synthesis ionic covalent organic frameworks/cotton composites for pipette tip solid-phase extraction of domoic acid in seafood. Talanta, 2024, 269, 125485.
20. Jinhua Xu, Zhenli Yu, Wenmin Zhang, Shiye Xie, Baodi Liao, Lan Zhang*. Zwitterionic covalent organic nanosheets for selective analysis of domoic acid in marine environment. Anal. Chim. Acta, 2024, 1331, 343343.
21. Wenmin Zhang, Baodi Liao, Shiye Xie, Lan Zhang*. Hollow microporous organic network fiber membrane for efficient extraction of okadaic acid from marine organism. J. Chromatogr. A, 2024, 1736, 465392.
22. Shiye Xie, Baodi Liao, Jing Yu, Wenmin Zhang, Hui Chen, Jinhua Xu, Lan Zhang*. Self-assembled flower-like carbon nanosheets for magnetic solid-phase extraction of microcystins from aquatic organism. J. Chromatogr. A, 2024, 1730, 465139.
23. Hui Chen, Wenmin Zhang, Guancheng Liu, Qingqing Ding, Jinhua Xu, Min Fang, Lan Zhang*. Highly sensitive detection of okadaic acid in seawater by magnetic solid-phase extraction based on low-cost metal/nitrogen-doped carbon nanotubes. J. Chromatogr. A, 2023, 1689, 463772.
24. Qingqing Ding, Wenmin Zhang, Yuheng Guo, Juan Wang, Hui Chen, Lan Zhang*. β-Lactamase Sensitive Probe for Rapid Detection of Antibiotic-Resistant Bacteria with Gas Chromatography-Tandem Mass Spectrometry. Anal. Chem., 2023, 95, 6098-6106.
25. Xueyi Zheng, Qiaocheng Feng, Jingru Chen, Jiaquan Yan, Xiaojing Li, Liangqia Guo*. Quantification analysis of microplastics released from disposable polystyrene tableware with fluorescent polymer staining. Sci. Total Environ., 2023, 864, 161155
26. Qiaocheng Feng, Xiaoyan Hu, Jingru Chen, Liangqia Guo*. Phosphorescent naphthalene-doped carbon nitride quantum dots for selective detection of polyamide microplastics. Anal. Chem., 2025, 97, 11066-11072.
27. Jingcheng Zheng, Weiwei Zhang, Yun Huang, Jiwei Shao, Yu Chen, Yuwu Chi*. Photochromic Cs2Pb(NO3)2Br2 perovskite nanosheets as a novel anti-counterfeiting material. Angew. Chem. Int. Ed., 2025, e202520855.
3. 食品安全快检技术与仪器
基于新型光电检测技术以及纳米技术开展食品安全在线监测预警溯源、便携式快速检测的关键技术、仪器及配套试剂的研发与成果转化。
部分代表性研究成果：
1. Cheng, Mengxin; Cao, Ying; Chen, Lifen*; Lin, Yue; Luo, Fang; Guo, Longhua; Qiu, Bin*; Lin, Zhenyu*. Portable Fluorescence Histamine Sensor for Freshness Assessing Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework. ACS Sens., 2025, 10, 4580−4588.
2. 陈晓萍，王旭潭，刘宁，汪庆祥，倪建聪，杨伟强*，林振宇*。MOFs基微流控电化学检测芯片对多种重金属离子的实时在线检测。高等学校化学学报，2024, 45(2), 20230395。
3. Huabin Cai, Yanling Huang, Yue Lin*, Fang Luo, Lifen Chen*, Longhua Guo, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin*. Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of Microchannel Using a Multimeter as Readout. ACS Sens., 2024, 9, 1, 494–501.
4. 生物分析与生物成像
围绕与食品污染有关的重大慢性病，如肿瘤等相关生物标志物开展体外检测、活细胞成像、活体原位诊断与治疗的新原理和新方法研究。
部分代表性研究成果：
1. Yu Xie, Jie-Hao Lin, Li-Yang Chen, Lei Feng, Zhi-Min Chen, Jia-Xing Zheng,2. Sai-Nan Qin, Guang-Wei Li, Kalle Salminen, Jian-Jun Sun*. Rapid nanomolar detection of ketamine in biofluids based on electrochemical aptamer-based sensor for drugged driving screening within 30 s. Sens. Actuators B: Chem., 2023, 390, 133903.
2. Yu Xie, Jin-Ping She, Jia-Xing Zheng, Kalle Salminen, Jian-Jun Sun*. Rapid nanomolar detection of Δ9-tetrahydrocannabinol in biofluids via electrochemical aptamer-based biosensor. Anal. Chim. Acta, 2024, 1295, 342304.
3. Yingshu Dai, Xixian Yan, Xinyi Xu, Nanyan Fu*. Viscosity-sensitive fluorescent probe reveals mitochondria-lysosome interactions in ferroptosis and Parkinson's disease. Sens. Actuators B: Chem., 2026, 447, 138789.
4. Yingshu Dai, Limei Xiao, Jiayang Liao, Zhengtao Han, Nanyan Fu*. Detecting changes in singlet oxygen and viscosity during apoptosis-ferroptosis mediated photodynamic therapy and establishing visual imaging of fatty liver. ACS Sens., 2025, 10, 2100-2112.
5. Di Wei, Yingshu Dai, Xixian Yan, Daoguo Lan, Jiayang Liao, Zhengbang Qin, Nanyan Fu*. A novel “double-responsive” and “dual-targeted” multifunctional fluorescent probe monitors the level changes of ONOO− in mitochondria during cell pyroptosis. ACS Sens., 2025, 10, 2542-2553.
6. Di Wei, Yingshu Dai, Jing Cao, Nanyan Fu*. A novel fluorescent probe for visualizing viscosity changes in lipid droplets during chemotherapy-induced ferroptosis. Anal. Chim. Acta, 2024, 1299, 342422.
7. Yingshu Dai, Jiajia Gong, Jing Cao, Wenxin Chen, Nanyan Fu*. A deep-red fluorescent probe based on naphthalimide for discrimination of HSA from BSA and tracking HSA by bioimaging. Dyes Pigm., 2024, 222, 111893.
8. Lan Rong, Jing Caoa, Yingshu Dai, Wenxin Chen, Nanyan Fu*. A bichromophoric squaraine based NIR fluorescent probe for G-quadruplex in living cells. Dyes Pigm., 2024, 227, 112159.
9. Zhichao Yu, Zhenjin Xu, Ruijin Zeng, Man Xu, Minglang Zou, Da Huang*, Zuquan Weng*, Dianping Tang*. Tailored Metal–Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis. Angew. Chem. Int. Ed., 2025, 64, e202420200.
10. Zhichao Yu, Zhenjin Xu, Ruijin Zeng, Man Xu, Haisu Zheng, Da Huang*, Zuquan Weng*, Dianping Tang*. D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance. Angew. Chem. Int. Ed., 2025, 64, e202414625.
11. Ruijin Zeng, Tongyu Liu, Minghao Qiu, Hao Tan, Yu Gu, Na Ye, Zhaoqi Dong, Lu Li, Fangxu Lin, Qiang Sun, Qinghua Zhang, Lin Gu, Mingchuan Luo, Dianping Tang, Shaojun Guo*. High-volumetric density atomic cobalt on multishell ZnxCd1-xS boosts photocatalytic CO2 reduction. J. Am. Chem. Soc., 2024, 146: 9721-9727.
12. Ruijin Zeng, Qian Gao, Limei Xiao, Weijun Wang, Yu Gu, Hengshuo Huang, Yingjun Tang, Dianping Tang, Shaojun Guo*. Precise tuning of the D-band center of dual-atomic enzymes for catalytic therapy. J. Am. Chem. Soc., 2024, 146: 10023-10031.
13. Haiyang Wang, Di Wu, Shuqun Lao, Dianping Tang*. Three-metal oxide hollow lamellar cube and oxygen vacancy engineering: Construction of a dual-mode sensing platform and collaborative detection mechanism. Anal. Chem., 2025, 97:19926-19933.
14. Zhichao Yu, Ruijin Zeng, Hexiang Gong, Yuan Gao, Shuyun Chen, Yunsen Wang, Dianping Tang*. Geometric and defects engineering collaborate for enhanced cascade enzymatic nanoreactors. Nano Res., 2024, 17(4): 2451-2461.
15. Yunsen Wang, Ruijin Zeng, Shuo Tian, Shuyun Chen, Zhilan Bi, Dianping Tang*, Dietmar Knopp*. Bimetallic single-atom nanozyme-based electrochemical-photothermal dual-function portable immunoassay with smartphone imaging. Anal. Chem., 2024, 96: 13663-13671.
16. Haiyang Wang, Juan Tang, Xinyu Wan, Xin Wang, Yongyi Zeng, Xiaolong Liu*, Dianping Tang*. Mechanism Exploration of the Photoelectrochemical Immunoassay for the Integration of Radical Generation with Self-Quenching. Anal. Chem., 2024, 96: 15503-15510.
17. Zhichao Yu, Man Xu, Di Wu, Jiao Qin, Dianping Tang*. Two-dimensional dissipative paper-based immunoassay with oxygen vacancy-enriched CeO₂ nanozymes for portable cancer screening. Anal. Chem., 2025, 97, 19783-19790.
18. Shuyun Chen, Zhichao Yu, Yunsen Wang, Juan Tang*, Yongyi Zeng*, Xiaolong Liu, Dianping Tang*. Block polymer restricted sub-nanometer Pt nanoclusters with nanozyme-enhanced immunoassay for monitoring of cardiac troponin I. Anal. Chem., 2023, 95: 14494-14501.
19. Ruijin Zeng, Yanli Li, Xuehan Hu, Weijun Wang, Yuxuan Li, Hexiang Gong, Jianhui Xu, Lingting Huang, Liling Lu, Yongfan Zhang, Dianping Tang*, Jibin Song*. Atomically-Site Synergistic effects of Dual-Atom Nanozyme Enhances Peroxidase-like Properties. Nano Lett. 2023, 23:6073-6080.
20. Zhichao Yu, Juan Tang*, Hexiang Gong, Yuan Gao, Yongyi Zeng, Dianping Tang*, Xiaolong Liu*. Enzyme-encapsulated protein trap engineered metal-organic framework-derived biomineral probes for non-invasive prostate cancer surveillance. Adv. Funct. Mater., 2023, 33, 2301457.
21. Ruijin Zeng, Linghui Lin, Hexiang Gong, Yuxuan Li, Jianhui Xu, Lingting Huang, Weijun Wang, Sen Lin, Dianping Tang*, Shaojun Guo*. Tuning the rate-determining step of uric acid electrooxidation over single-atom site metal centers for high-performing sensing. Chem Catal., 2023, 3: 100514.
22. Akang Dan, Jiahao Yuan, Peisi Xie, Jing Chen, Canrong Chen, Zian Lin*, Zongwei Cai*. Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut–Brain Axis. Environ. Sci. Technol., 2025, 59, 27, 13671-13682.
23. Wen Xie, Yajing Zhang, Yu He, Hang Su, Jinni Zhang, Canrong Chen, Peisi Xie, Jing Chen, Zian Lin*, Zongwei Cai*. Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation. Environ. Sci. Technol., 2025, 59, 36, 19160-19171.
24. Dan Ouyang, Huan Huang, Yanting He, Jiajing Chen, Jiali Lin, Zhuling Chen, Zongwei Cai, and Zian Lin*. Utilization of Hydralazine as A Reactive Matrix for Enhanced Detection and On-MALDI-Target Derivatization of Saccharides, Chin. Chem. Lett., 2024, 35, 412-417.
25. Dan Ouyang, Chuanzhe Wang, Chao Zhong, Juan Lin, Gang Xu, Guane Wang* and Zian Lin*. Organic Metal Chalcogenides-Assisted Metabolic Molecular Diagnosis of Central Precocious Puberty. Chem. Sci., 2024, 15, 278-284.
26. Dan Ouyang, Akang Dan, Zian Lin* and Zongwei Cai*. Spherical Covalent-Organic Framework-Assisted Laser Desorption Ionization Mass Spectrometry Reveals the Promotional Effect of Triphenyl Phosphate on Breast Cancer in Mice. Sci. Total Environ., 2024, 955, 177155.
27. Jingjing Yan, Wen Xie, Yingxue Jin, Zongwei Cai, and Zian Lin*. 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic Acid as a Novel MALDI Matrix for Analysis and Evaluation of Imidacloprid-Induced Metabolomic Changes in Mouse Serum. Talanta, 2025, 286, 127536.
28. Yingxue Jin, Dan Ouyang, Qi Wen, Juan Lin, Zongwei Cai, Zian Lin*. Stacking-Directed Energy Modulation in Covalent Organic Framework Thin Films for enhanced Serum Metabolic Profiling of MP by LDI-MS. Anal. Chem., 2025, 97, 21530-21537.
29. Yue Lin, Peiqing Luo, Fang Luo, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin *, Jinzhuan Chen*. High-Sensitivity Homogeneous Detection of miRNA-155 Governed by DNA Walker-Regulated Surface DNA Density of Magnetic Electrochemiluminescence Nanoparticles. Anal. Chem., 2024, 96, 33, 13710-13718.
30. Ming Chen, Hongfu Zeng, Fang Luo, Yunjian Huang*, Cuiying Lin*, Jian Wang, Bin Qiu, Zhenyu Lin*. Electrochemiluminescence Biosensor for Ascorbic Acid Based on target transformation of Cell-Free RNA Transcription System and Duplex Specific Nuclease-assisted Recycling Amplification. Anal. Chem., 2024, 96, 44, 17807-17813.
31. Mengfan Mao, Shengfei Liu, Xiaolong Zhong, Yue Lin, Cuiying Lin, Guoqing Hu, Kang Liang*, Chuanhui Huang*, and Zhenyu Lin*. Raising enzymatic stability during biocatalysis with hierarchically hollow twodimensional MOF nanocapsules. Cell Rep. Phys. Sci., 2024, 5, 102285.
32. Qin Luo, Mengjian Tian, Fang Luo, Min Zhao*, Cuiying Lin*, Bin Qiu, Jian Wang, Zhenyu Lin*. Multicolor biosensor for trypsin detection based on the regulation of bovine serum albumin-coated gold nanoclusters peroxidase activity and etching of gold nanobipyramids. Anal. Chem., 2023, 95, 4, 2390–2397.
33. Peiqing Luo, Xiaocui Huang, Fang Luo, Zhonghui Chen*, Yu Chen, Cuiying Lin, Jian Wang, Bin Qiu*, Zhenyu Lin*. Low background signal-on homogeneous electrochemiluminescence biosensor for HBV detection based on the regulation of length of DNA modified on the nanoparticles by CRISPR/Cas12a and hybridization chain reaction. Anal. Chem., 2023, 95, 37, 14127–14134.
34. Tian, Shaohua; Yuan, Yong; Luo, Fang; Lin, Cuiying*; Wang, Jian; Qiu, Bin; Lin, Zhenyu*, Wang, Weijia*. Dual self-amplification homogeneous electrochemiluminescence biosensor for terminal deoxynucleotidyl transferase activity based on controlling the surface morphology and charge of reporter nanoparticles. Anal. Chem., 2023, 95, 50, 18603–18610.
35. Yuandi Xue, Xian Chen, Fan Wu, Canrong Chen, Na Lin, Shaofeng Dong, Ying Sun, Zian Lin*. A Self-Oxidizing o-Dihydroxybenzene-Based Covalent Organic Framework Hydrogel with Broad-Spectrum Antibacterial Properties for Promoting Diabetic Wound Healing. Adv. Funct. Mater., 2025, 35, 2505669.
36. Xiao Fang, Yue Wu, Yaling Dai, Han Xiao, Shiqing Li, Xiaoning Chen, Meng Yuan, Yanbei Guo, Liying Ma, Dingyue Lin, Weilin Liu, Chunhua Lu*, and Huanghao Yang*. In Situ Recovery of Serotonin Synthesis by a Tryptophan Hydroxylase-Like Nanozyme for the Treatment of Depression. J. Am. Chem. Soc., 2025,147, 9111-9121.
37.Shiqing Li, Tao Zeng, Zhixing Wu, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Qi Chen, Chunsen Li, Chunhua Lu*, and Huanghao Yang*. DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor. Targeting. J. Am. Chem. Soc., 2025, 147, 2168-2181.
38. Yana Liu, Tao Zeng, Shiyan Bai, Xiao Fang, Xiuping Cao, Shiqing Li, Qi Chen, Chunhua Lu*, and Huanghao Yang*. Light Triggered “Bacterial Bomb”to Amplify Tumor Pyroptosis. Adv. Funct. Mater., 2025, 2505784.
39. Xiuping Cao, Liyang Fang, Yifan Jiang, Tao Zeng, Shiyan Bai, Shiqing Li, Yana Liu, Wukun Zhong, Chunhua Lu*, Huanghao Yang*. Nanoscale octopus guiding telomere entanglement: An innovative strategy for inducing apoptosis in cancer cells. Biomaterials, 2025, 313, 122777.
40. Wukun Zhong, Saijie Wang, Chunyang Geng, Yanlin Zheng, Shiyan Bai, Xiuping Cao, Kai Liu, Yang Yang, Chunhua Lu*, Xingyu Jiang. Multiplexed Random Access Approach to DNA Microspheres for High-Capacity Data Storage. Adv. Funct. Mater., 2024, 34(48), 2408852.
41. Wukun Zhong, Chunyang Geng, Zhangcheng Fu, Cuiping Mao, Yanlin Zheng, Saijie Wang, Kai Liu, Yang Yang, Chunhua Lu*, Xingyu Jiang*. Flow Cytometry Sorting for Random Access in DNA Data Storage: Encapsulation for Enhanced Stability and Sequence Integrity of DNA. Anal. Chem., 2024, 96(40), 16099-16108.
42. Xiao Fang, Meng Yuan, Fang Zhao, Aoling Yu, Qianying Lin, Shiqing Li, Huichen Li, Xinyang Wang, Yanbin Yu, XinWang, Qitian Lin, Chunhua Lu* and Huanghao Yang*. In situ Continuous Dopa Supply by Responsive Artificial Enzyme for the Treatment of Parkinson’s Disease. Nat. Commun., 2023, 14, 2661.
43. Yana Liu, Tao Zeng, Chuang Liu, Xiao Fang, Shiqing Li, Xiuping Cao, Chunhua Lu*, and Huanghao Yang. DNA Origami-Based Letterpress Printing of Gold Nanostructures with Predesigned Morphologies. Nano Lett., 2023, 23, 11569-11577.
44. Tao Zeng, Weijie Zang, Han Xiao, Yifan Jiang, Sang Lin, Min Wang, Shiqing Li, Liannishang Li, Chunsen Li, Chunhua Lu*, and Huanghao Yang*. Carrier-Free Nanovaccine: An Innovative Strategy for Ultrahigh Melanoma Neoantigen Loading. ACS Nano, 2023, 17, 18114-18127.
45. Lei-Xin Jin, Qi-Meng Wang, Shu-Jiao Zhu, Cai-Lian Zhu, Jian-Jun Sun, Shao-Hua Wu*. Gold nanocube-enhanced SERS biosensor based on heated electrode coupled with exonuclease III-assisted cycle amplification for sensitive detection of flap endonuclease 1 activity, Talanta, 2025, 286, 127500.
46. Zhen-Zhen Mi, Hao-Cheng Hu, Jian-Jun Sun, Shao-Hua Wu*. Heating promoted super sensitive electrochemical detection of p53 gene based on alkaline phosphatase and nicking endonuclease Nt.BstNBI-assisted target recycling amplification strategy at heated gold disk electrode. Anal. Chim. Acta, 2023, 1275, 341583.
47. Zhongzhu Hong, Zhaowei Chen, Qiushui Chen*, Huanghao Yang*. Advancing X-ray Luminescence for Imaging, Biosensing, and Theragnostics. Acc. Chem. Res., 2023, 56, 37-51.
48. Zhongzhu Hong, Shuai He, Qinxia Wu, Xiaofeng Chen, Zhijian Yang, Xiaoze Wang, Shuheng Dai, Shumeng Bai, Qiushui Chen*, Huanghao Yang*. One-Pot Synthesis of Lanthanide-Activated NaBiF4 Nanoscintillators for High-Resolution X-ray Luminescence Imaging. J. Lumin., 2023, 254, 119492.
49. Qinxia Wu, Qianyu Zheng, Yu He, Qiushui Chen*, Huanghao Yang*. Emerging Nanoagents for Medical X-ray Imaging. Anal. Chem., 2023, 95, 33-48.
50. Zhijian Yang, Peng Zhang, Xiaofeng Chen, Zhongzhu Hong, Jianwei Gong, Xiangyu Ou, Qinxia Wu, Weihong Li, Xiaoze Wang, Lili Xie, Zhenzhen Zhang, Zhiyang Yu, Xian Qin, Jiang Tang, Hongjie Zhang, Qiushui Chen*, Sanyang Han, Huanghao Yang*. High-Confidentiality X-Ray Imaging Encryption Using Prolonged Imperceptible Radioluminescence Memory Scintillators. Adv. Mater., 2023, 35, 2309413.
51. Minle Chen, Yijuan Jiang, Yongjie Zhang, Xiaoling Chen, Lei Xie, Lili Xie, Tao Zeng, Yana Liu, Hao Liu, Min Wang, Xiaofeng Chen, Zhenzhen Zhang, Yu He, Xian Qin, Chunhua Lu, Qiushui Chen*, Huanghao Yang*. Visualization of Biomolecular Radiation Damage at the Single-Particle Level Using Lanthanide-Sensitized DNA Origami. Nano Lett., 2024, 24(37): 11690-11696.
52. Xiangyu Ou, Zhongzhu Hong, Qinxia Wu, Xiaofeng Chen, Lili Xie, Zhenzhen Zhang, Yu He, Qiushui Chen*, Huanghao Yang*. Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors. ACS Nano, 2024, 18(40): 27126-27137.
53. Qinxia Wu, Xinqi Xu, Xiaokun Li, Hao Jiang, Xian Qin, Zhongzhu Hong, Xiaofeng Chen, Zhijian Yang, Xiangyu Ou, Lili Xie, Yu He, Sanyang Han, Qiushui Chen*, Huanghao Yang*. Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging. Angew. Chem. Int. Ed., 2024, 63, e202404177.
54. Yanzhe Qin, Stephan A. Koehler, Yunyan Ling, Shiqiang Yu, Yongjie Zhang, Jie Luo, Kaijian Chen, Luo Junjie, Junjie Zeng, Haiyang Chu, Fei Wang, Wei Li, Dan Li, Xinran Yu, Xiangchao Wu, Shengming Zhao, Hao Lu, Ziqing Deng, Zhijian Yang, Ruibin Mai, Zhuo Liu, Zihua Niu, Xin Huang, Chengmei Xing, Xingcai Zhang, Yongyou Hu, Xinwen Peng, Xiaoxing Liao, Xiangmeng Qu, Yiming Gong, Qiushui Chen*, Thomas M. Hermans, Wenwei Zhang, Huanghao Yang*. Fast, Cost-Effective and Flexible DNA Sequencing by Roll-to-Roll Fluidics. Nat. Methods, 2025, 22, 1662-1668.