报告题目：超声于大脑药物与基因递送

报告人：叶秩光  台湾新竹清华大学

时间：2018年3月9日(星期五)下午3:30

地点：福州大学旗山校区嘉锡楼413

报告人简介：

    叶秩光，教授，现任台湾新竹清华大学生医工程与环境科学系特聘教授。叶秩光教授于2004年在台湾大学获得博士学位，于2002-2003年在加利福尼亚大学戴维斯分校访问研究，于2005年进入台湾新竹清华大学。曾获得台湾新竹清华大学教师学术卓越奖励、杰出产学研究奖、杰出学术研究出版奖励、台湾科技部大专生研究创造奖、台湾国科会大专生研究创造奖等。已在国际权威刊物发表SCI论文共115余篇。

学术报告简介：

Ultrasound Targeted CNS Gene Delivery for Parkinson’s Disease Treatment

      Parkinson’s disease (PD) is a potent neurodegenerative disease in which a progressive loss of dopaminergic neurons eventually produces a loss of movement controlling ability and other symptoms. To date, in addition to pharmacological, non-pharmacological, and neurosurgical therapies, gene delivery has emerged as a potential therapeutic modality for PD. Effective targeted gene delivery is complicated in that gene vectors cannot penetrate the blood-brain barrier (BBB), thus clinical tests must rely on invasive intracerebral gene vector injection. Burst low-pressure focused ultrasound exposure with the microbubbles has been shown to noninvasively target and temporally open the BBB, opening new opportunities to transport large molecule substances into the brain for central nervous system (CNS) disease treatment, and raising the potential for noninvasive gene delivery for PD treatment. This paper reviews the underlying mechanism and current progress for focused ultrasound induced CNS gene delivery, and summarizes potential directions for further ultrasound-medicated PD gene therapy.