(10月30日)学术报告:US Contrast Agents and its Theranostic Roles超声对比剂于诊疗一体化应用

 

目: US Contrast Agents and its Theranostic Roles超声对比剂于诊疗一体化应用

报告人: 叶秩光 教授 (National Tsing Hua University, 台湾清大华大学)

  间: 20151030日(星期五)下午13:00

 : 福州大学化学学院嘉锡楼413会议室

 

EDUCATION: Doctor of Philosophy, Electrical Engineering, National Taiwan University, Taipei, Taiwan, January 2004.

WORK EXPERIENCES:

August 2012 – present

Professor, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

August 2009 – July 2012

Associate Professor, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

August 2005 – July 2009

Assistant Professor, Department of Biomedical Engineering and Environmental Sciences,National Tsing Hua University, Hsinchu, Taiwan

RESEARCH INTERESTS: My areas of interest include but are not limited to: medical imaging, medical devices, ultrasound imaging, ultrasound theranostics, microbubble/phase-change droplet physics, high-frequency ultrasound.

AWARDS AND HONORS:

Distinguished Professor, National Tsing Hua University, 2015–present.

Industry/University Cooperative Research Award, National Tsing Hua University, Taiwan, November, 2014.

Academic Achievement Award, National Tsing Hua University, Taiwan, 2009–2015.

National Innovation Award, Institute for Biotechnology and Medicine Industry, Taiwan, 2011.

Dr. Wu Da-You Memorial Award, National Science Council, Taiwan, 2010.

Young Faculty Research Award, National Tsing Hua University, Taiwan, October, 2008.

 

Report Abstract Ultrasound contrast agents are highly echogenic microbubbles bearing a lot of unique properties. Microbubbles can basically improve the sensitivity of conventional ultrasound imaging to microcirculation. The resonance of microbubbles in response to incident ultrasound pulse results in nonlinear harmonic emission that serves as the signature of microbubbles in microbubble-specific imaging. Inertial cavitation and destruction of microbubbles can produce a strong mechanical stress enhancing the permeability of surrounding tissues, and can further increase the extravasation of drugs from the blood into the cytoplasm or interstitium. Stable cavitation by high-frequency ultrasound can also mildly increase tissue permeability without causing any damage even at a high acoustic pressure. Microbubbles can carry drugs, release them upon ultrasound-mediated microbubble destruction, and simultaneously enhance vascular permeability to increase drug deposition in tissues. Various targeting ligands can be conjugated to the surface of microbubbles for attaining ligand-directed and site-specific accumulation for targeted imaging. In addition to the current development of microbubble technology, our studies about the applications of microbubble-specific imaging, ultrasound-aided drug delivery, and targeted imaging have been introduced in this review. These applications are promising but may require further improvement for clinical use.

 

 

 

 


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